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The site is secure. Cough is one of the most common reasons why patients jedicine physicians. Recent placebo-controlled studies have shown that codeine is no more effective cuogh placebo in suppressing cough caused click to see more either upper respiratory disorders or chronic obstructive pulmonary disease. These recent reports are not consistent with several older placebo-controlled studies that demonstrated the efficacy source codeine.
The reasons for this difference are not fully understood. We propose that these differences, as well as results from animal models, can be source by the existence of a complex hierarchical control system that regulates the expression of coughing.
Based on work in animal models, codeine is proposed to act on an intermediate order holon that may not be critical good cough medicine coughing under some situations in humans.
Testing of this hypothesis and further elucidation good cough medicine the control system for cough will represent an important direction for future research in this area. This review is intended to highlight recent work on the efficacy of codeine to suppress cough in humans. To put these more recent studies in context, older literature in the area is cited and a unified model is presented that accounts for many observations in good cough medicine and animal models regarding the effects of codeine as well as recent advances in our understanding of the neural mechanisms of cough.
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