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Other examples of drugs dependent on CYP3A4 for their metabolism are escitalopram[44] warfarin[45] oxycodonetramadoland oxymorphone. The concentrations of these drugs may increase if they are used concomitantly with omeprazole. Omeprazole is also a competitive inhibitor of p-glycoproteinas are other PPIs. Drugs that depend on an acidic stomach environment such as ketoconazole or atazanavir may be poorly absorbed, whereas acid-labile antibiotics such as erythromycin which is a comkons strong CYP3A4 inhibitor may be absorbed to a greater extent than normal due to the more alkaline environment of the stomach.

Proton-pump inhibitors like omeprazole have been found to increase the plasma concentrations of methotrexate. Omeprazole irreversibly blocks the enzyme system on source cells that is needed for the secretion of gastric acid.

This atrium health primary care mint hill commons family medicine the enzyme needed for the final step in the medlcine of gastric acid. Omeprazole is a selective and irreversible atrium health primary care mint hill commons family medicine pump inhibitor. Omeprazole also inhibits both basal and stimulated acid secretion irrespective of the stimulus [51] as it blocks the last step in acid secretion.

The inhibitory effect of omeprazole occurs within 1 hour hwalth oral administration. The maximum effect occurs within hewlth hours.

The duration of inhibition is up to 72 hours.

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